UMBC High Performance Computing Facility
Molecular modeling of effects of phosphorylation on proteins
Dr. Lasse Lindahl, Faculty, Biology
Dr. Ian Thorpe, Faculty, Chemistry
Dr. Bruce Johnson, Faculty, Chemistry
Nusrat Rahman, Grad Student, Biology
Post-translational modifications, like phosphorylation, acetylation,
affects a proteins charge, hydrophobicity, which results in changes in
the protein's conformation, binding properties etc. The project will use
molecular simulation tools (eg. Gromacs) to simulate effect of
phosphorylation of ribosomal protein L5 on its binding to 5S rRNA.